Aspergillus – Molecular Biology & Genetics

Genetics and Molecular Biology

Molecular biology of Aspergillus allergens.

Allergic Bronchopulmonary Aspergillosis (ABPA) is a severe respiratory disease caused by the fungus Aspergillus fumigatus (Af). It occurs as secondary complication mostly in patients with atopy and cystic fibrosis. The standardized and well-characterized allergens are essential for the immunodiagnosis of ABPA as well as for understanding the pathophysiology of the disease. Molecular cloning was...

Pneumoviruses: Molecular Genetics and Reverse Genetics

Pneumoviruses are responsible for significant respiratory disease in their hosts and represent a major problemfor human and animal health. Pneumoviruses are members of the family Paramyxoviridae, subfamilyPneumovirinae and the virus particles consist of a negative-sense, nonsegmented RNA genome within a helical nucleocapsid structure enveloped in a lipid membrane derived from the ho...

Statistical Applications in Genetics and Molecular Biology

An important challenge in statistical genomics concerns integrating experimental data with exogenous information about gene function. A number of statistical methods are available to address this challenge, but most do not accommodate complexities in the functional record. To infer activity of a functional category (e.g., a gene ontology term), most methods use gene-level data on that category,...

Molecular biology and genetics of tubulin.

PERSPECTIVES AND SUMMARY .............................................................. 332 HETEROGENEITY OF TUBULIN POLYPEPTIDES: AN HISTORICAL CHRONICAL ............................................................................ 334 COMPLEXITY OF TUBULIN GENE SEQUENCES .......................................... 336 Tubulin Genes in Unicellular Organisms .........................................